- Horror on a global scale – No longer confined to a specific location, the outbreak of the C-virus is worldwide with the action taking place in North America, Eastern Europe and China
- Multiple characters and intertwined storylines – Experience the horror playing as Leon S. Kennedy, Chris Redfield, and Jake Muller with their respective partners
- Solo or co-op – Resident Evil 6 delivers both single and co-op gameplay either offline or online
- Zombies make a return to the Resident Evil series, but can now run, jump at players and even use weapons, making them far more challenging than in previous games
- The enemy creatures known as J’avo first came to prominence in the conflict zone of Eastern Europe and have the ability to regenerate when injured; furthermore, if J’avo take substantial damage to a particular area, they can mutate the affected body part into a variety of different forms, meaning players will have to rethink their strategy and adapt to this unpredictability
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